| San Marco | | Tourist epicenter, dramatic, historic | $200-600/night | First visits, splurges, honeymoons | Vaporetto stops San Marco Vallaresso (lines 1, 2) and San Zaccaria (lines 1, 4.1, 4.2) within 5 minutes |
| Dorsoduro | | Local, artsy, canal-side promenades | $150-350/night | Repeat visitors, couples, art lovers | Vaporetto stops Accademia (lines 1, 2) and Zattere (lines 2, 4.1, 5.1) |
| Cannaregio | | Authentic neighborhood, Jewish Ghetto | $100-280/night | Budget travelers, train arrivals | Ferrovia stop (all lines) adjacent to train station; Ca' d'Oro (line 1) in the center |
| San Polo | | Market energy, central, food-focused | $130-320/night | Foodies, best overall location | Vaporetto stops Rialto Mercato (line 1) and San Silvestro (line 1) |
| Castello | | Residential, quiet, working-class east | $90-250/night | Quiet nights, second visits, photographers | Vaporetto stops Arsenale (line 1), Giardini (line 1), San Zaccaria (lines 1, 4.1, 4.2) |
| Giudecca | | Island, panoramic views, genuinely local | $80-200/night | Budget travelers, views, peace | Vaporetto lines 2 and 4.1/4.2 run every 10 to 12 minutes from Palanca, Redentore, and Zitelle stops |